Gene Editing for Stem Cell Biology

Simple, efficient, targeted genome editing via the CompoZr™ Zinc Finger Nuclease technology allows easy creation of novel cell lines and model organisms with precise and heritable gene additions, deletions, or modifications.

This powerful, breakthrough technology holds great promise for Stem Cell Research, as well as the broader life science community.

Case studies

• ZFN Publications
• Targeted gene addition into a specified location in the human genome using designed zinc finger nucleases PNAS 2007 104:3055-3060
• Targeted gene knockout in mammalian cells by using engineered zinc-finger nucleases PNAS 2008 105:5809-5814
• Highly efficient endogenous human gene correction using designed zinc-finger nucleases Nature 435, 646 - 651 (03 Apr 2005)
• Gene editing in human stem cells using zinc finger nucleases and integrase-defective lentiviral vector delivery Nature Biotechnology 25, 1298 - 1306 (28 Oct 2007)
• An improved zinc-finger nuclease architecture for highly specific genome editing Nature Biotechnology 25, 778 - 785 (01 Jul 2007)

Associated products

• CompoZr

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